A recent report published in the European Heart Journal has found that xylitol, an artificial sugar substitute commonly found in items like chewing gum, peanut butter, and baked goods, may increase the risk of heart attack and stroke. The study suggests that xylitol might impair the body's clotting abilities, potentially leading to cardiovascular events.
While xylitol has received Generally Recognized as Safe (GRAS) status from the Food and Drug Administration, research indicates that artificial sweeteners like xylitol may have negative impacts on multiple body systems. The study, conducted by researchers analyzing blood samples from over 3,000 individuals, found that those with the highest levels of xylitol in their blood had double the risk of heart attack, stroke, and death compared to those with lower levels.
The study also included in vivo, interventional, and rodent experiments to understand how xylitol affects cardiovascular function, with findings suggesting that the sweetener impacts platelet function. This increased stickiness of platelets in the bloodstream could potentially lead to clotting in the brain and heart, triggering cardiovascular events.
While the study identifies an association between xylitol and cardiovascular events, more research is needed to determine a causal relationship. It is important to note that this study is observational and does not definitively prove that xylitol directly causes cardiovascular problems.
Researchers and medical professionals advise limiting consumption of xylitol, especially for individuals with obesity, diabetes, or metabolic syndrome, who may be more vulnerable to the potential risks associated with the artificial sweetener. Ultimately, the findings underscore the importance of clinicians having comprehensive conversations with their patients about the potential risks of xylitol and tailoring dietary recommendations accordingly.